Topical versus intravenous tranexamic acid in total knee arthroplasty.
Identifieur interne : 000255 ( Main/Exploration ); précédent : 000254; suivant : 000256Topical versus intravenous tranexamic acid in total knee arthroplasty.
Auteurs : Brian R. Hamlin [États-Unis] ; Anthony M. Digioia [États-Unis] ; Anton Y. Plakseychuk [États-Unis] ; Tim J. Levison [États-Unis]Source :
- The Journal of arthroplasty [ 1532-8406 ] ; 2015.
Descripteurs français
- KwdFr :
- Acide tranéxamique (administration et posologie), Administration par voie intraveineuse, Administration par voie topique, Adulte d'âge moyen, Antifibrinolytiques (administration et posologie), Arthroplastie prothétique de genou, Femelle, Humains, Hémorragie postopératoire (), Mâle, Perte sanguine peropératoire (), Sujet âgé, Transfusion sanguine.
- MESH :
- administration et posologie : Acide tranéxamique, Antifibrinolytiques.
- Administration par voie intraveineuse, Administration par voie topique, Adulte d'âge moyen, Arthroplastie prothétique de genou, Femelle, Humains, Hémorragie postopératoire, Mâle, Perte sanguine peropératoire, Sujet âgé, Transfusion sanguine.
English descriptors
- KwdEn :
- Administration, Intravenous, Administration, Topical, Aged, Antifibrinolytic Agents (administration & dosage), Arthroplasty, Replacement, Knee, Blood Loss, Surgical (prevention & control), Blood Transfusion, Female, Humans, Male, Middle Aged, Postoperative Hemorrhage (prevention & control), Postoperative Hemorrhage (therapy), Tranexamic Acid (administration & dosage).
- MESH :
- chemical , administration & dosage : Antifibrinolytic Agents, Tranexamic Acid.
- prevention & control : Blood Loss, Surgical, Postoperative Hemorrhage.
- therapy : Postoperative Hemorrhage.
- Administration, Intravenous, Administration, Topical, Aged, Arthroplasty, Replacement, Knee, Blood Transfusion, Female, Humans, Male, Middle Aged.
Abstract
The objective of this study is to compare the effectiveness of intravenous versus topical application of tranexamic acid in patients undergoing knee arthroplasty. All patients who underwent primary knee arthroplasty at our total joint center over a 12-month period were included in the study. One surgeon utilized 1 g of IV TXA at time of incision in all patients (n=373) except those with a documented history of venous thromboembolism (VTE). Two surgeons utilized a topical application of TXA for all patients without exception (n=198) in which the joint was injected after capsular closure with 3 g TXA/100 mL saline. The transfusion rate was 0% in the topical group vs. 2.4% in the IV group and this was statistically significant (P<0.05).
DOI: 10.1016/j.arth.2014.10.007
PubMed: 25458092
Affiliations:
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Le document en format XML
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Hamlin</name><affiliation wicri:level="2"><nlm:affiliation>The Bone & Joint Center, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Bone & Joint Center, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Digioia, Anthony M" sort="Digioia, Anthony M" uniqKey="Digioia A" first="Anthony M" last="Digioia">Anthony M. Digioia</name><affiliation wicri:level="2"><nlm:affiliation>The Bone & Joint Center, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>The Bone & Joint Center, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Plakseychuk, Anton Y" sort="Plakseychuk, Anton Y" uniqKey="Plakseychuk A" first="Anton Y" last="Plakseychuk">Anton Y. 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All patients who underwent primary knee arthroplasty at our total joint center over a 12-month period were included in the study. One surgeon utilized 1 g of IV TXA at time of incision in all patients (n=373) except those with a documented history of venous thromboembolism (VTE). Two surgeons utilized a topical application of TXA for all patients without exception (n=198) in which the joint was injected after capsular closure with 3 g TXA/100 mL saline. The transfusion rate was 0% in the topical group vs. 2.4% in the IV group and this was statistically significant (P<0.05).</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Hamlin, Brian R" sort="Hamlin, Brian R" uniqKey="Hamlin B" first="Brian R" last="Hamlin">Brian R. Hamlin</name></region><name sortKey="Digioia, Anthony M" sort="Digioia, Anthony M" uniqKey="Digioia A" first="Anthony M" last="Digioia">Anthony M. Digioia</name><name sortKey="Levison, Tim J" sort="Levison, Tim J" uniqKey="Levison T" first="Tim J" last="Levison">Tim J. Levison</name><name sortKey="Plakseychuk, Anton Y" sort="Plakseychuk, Anton Y" uniqKey="Plakseychuk A" first="Anton Y" last="Plakseychuk">Anton Y. Plakseychuk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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